Fluorinated α-aminophosphonates—a new type of irreversible inhibitors of serine hydrolases
نویسندگان
چکیده
منابع مشابه
Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases.
Serine hydrolase inhibitors, which facilitate enzyme function assignment and are used to treat a range of human disorders, often act by an irreversible mechanism that involves covalent modification of the serine hydrolase catalytic nucleophile. The portion of mammalian serine hydrolases for which selective inhibitors have been developed, however, remains small. Here, we show that N-hydroxyhydan...
متن کاملIrreversible inhibitors of serine, cysteine, and threonine proteases.
F. Vinyl Sulfones and Other Michael Acceptors 4683 G. Azodicarboxamides 4695 IV. Acylating Agents 4695 A. Aza-peptides 4695 B. Carbamates 4699 C. Peptidyl Acyl Hydroxamates 4700 D. â-Lactams and Related Inhibitors 4704 E. Heterocyclic Inhibitors 4714 1. Isocoumarins 4715 2. Benzoxazinones 4722 3. Saccharins 4725 4. Miscellaneous Heterocyclic Inhibitors 4728 V. Phosphonylation Agents 4728 A. Pep...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
The expanding diversity of serine hydrolases.
Serine hydrolases use a hydroxyl of a serine, assisted by one or more other residues, to cleave peptide bonds. They belong to several different families whose general mechanism is well known. However, the subtle structural differences that have recently been observed across a variety of families shed light on their functional diversity, including variations in mechanism of action, differences i...
متن کاملSelective and diagnostic labelling of serine hydrolases with reactive phosphonate inhibitors.
Reactive phosphonates are important probes to target the active site of serine hydrolases, one of the largest and most diverse family of enzymes. Developing such inhibitory probes is of special importance in activity based protein profiling, a strategy that is increasingly used to gain information about a certain class of enzymes in complex proteosomes. Therefore, gaining detailed information a...
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ژورنال
عنوان ژورنال: Doklady Biochemistry and Biophysics
سال: 2005
ISSN: 1607-6729,1608-3091
DOI: 10.1007/s10628-005-0041-7